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Article

β3 integrin promotes TGF-β1/H2O2/HOCl-mediated induction of metastatic phenotype of hepatocellular carcinoma cells by enhancing TGF-β1 signaling.

PloS one - 1 Jan 2013

Feng Xin-Xia, Liu Mei, Yan Wei, Zhou Zhen-Zhen, Xia Yu-Jia, Tu Wei, Li Pei-Yuan, Tian De-An

Abstract excerpt

In addition to being an important mediator of migration and invasion of tumor cells, β3 integrin can also enhance TGF-β1 signaling. However, it is not known whether β3 might influence the induction of metastatic phenotype of tumor cells, especially non-metastatic tumor cells which express low level of β3. Here we report that H2O2 and HOCl, the reactive oxygen species produced by neutrophils, could cooperate with...

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Identifiers

PMID: 24260309
DOI: 10.1371/journal.pone.0079857
PMCID: PMC3832483

Genes

SNAI2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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