Article
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
The Journal of biological chemistry - 25 Sept 2009
Larson Eric T, Parussini Fabiola, Huynh My-Hang, Giebel Jonathan D, Kelley Angela M, Zhang Li, Bogyo Matthew, Merritt Ethan A, Carruthers Vern B
Abstract excerpt
The protozoan parasite Toxoplasma gondii relies on post-translational modification, including proteolysis, of proteins required for recognition and invasion of host cells. We have characterized the T. gondii cysteine protease cathepsin L (TgCPL), one of five cathepsins found in the T. gondii genome. We show that TgCPL is the primary target of the compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl...
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