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Cysteine Protease Inhibitors Block <i>Toxoplasma gondii</i> Microneme Secretion and Cell Invasion

5 Dec 2006

Abstract excerpt

Toxoplasma gondii enters host cells via an active, self-driven process to fulfill its need for intracellular replication and survival. Successful host cell invasion is governed by sequential release of secretory proteins from three specialized organelles, including the micronemes, which contribute adhesive proteins necessary for parasite attachment and penetration. Cumulative evidence from studies of Trypanosoma...

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PMID: 17145790
DOI: 10.1128/aac.01059-06

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