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Article

Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation.

Nucleic acids research - 1 Sept 2009

Fu Guangsen, Wu Jinjun, Liu Wei, Zhu Deyu, Hu Yonglin, Deng Jiaoyu, Zhang Xian-En, Bi Lijun, Wang Da-Cheng

Abstract excerpt

DNA gyrase is an indispensible marvelous molecular machine in manipulating the DNA topology for the prokaryotes. In the 'two-gate' mechanism of DNA topoisomerase, T-segment navigation from N- to DNA-gate is a critical step, but the structural basis supporting this scheme is unclear. The crystal structure of DNA gyrase B' subfragment from Mycobacterium tuberculosis reveals an intrinsic homodimer. The two subunits,...

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Identifiers

PMID: 19596812
DOI: 10.1093/nar/gkp586
PMCID: PMC2761264

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