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Article

The pivot point arginines identified in the β-pinwheel structure of C-terminal domain from Salmonella Typhi DNA Gyrase A subunit.

Scientific reports - 8 May 2020

Sachdeva Ekta, Kaur Gurpreet, Tiwari Pragya, Gupta Deepali, Singh Tej P, Ethayathulla Abdul S, Kaur Punit

Abstract excerpt

The essentiality of DNA Gyrase in basic cellular processes in bacterial pathogens makes it an ideal drug target. Though the Gyrase has a conserved mechanism of action, the complete DNA wrapping and binding process is still unknown. In this study, we have identified six arginine residues R556, R612, R667, R716, R766, and R817 in the DNA GyraseA - C-terminal domain from Salmonella enterica serovar Typhi...

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Identifiers

PMID: 32385379
DOI: 10.1038/s41598-020-64792-w
PMCID: PMC7210945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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