Article
Oligomerization of Bacillus subtilis DesR is required for fine tuning regulation of membrane fluidity.
Biochimica et biophysica acta - 1 Oct 2009
Najle Sebastián R, Inda María E, de Mendoza Diego, Cybulski Larisa E
Abstract excerpt
BACKGROUND: The DesK-DesR two-component system regulates the order of membrane lipids in the bacterium Bacillus subtilis by controlling the expression of the des gene coding for the delta 5-acyl-lipid desaturase. To activate des transcription, the membrane-bound histidine kinase DesK phosphorylates the response regulator DesR. This covalent modification of the regulatory domain of dimeric DesR promotes, in a...
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