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Article

Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization.

The Journal of biological chemistry - 5 Oct 2007

Paul Ralf, Abel Sören, Wassmann Paul, Beck Andreas, Heerklotz Heiko, Jenal Urs

Abstract excerpt

Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP. Despite their importance and abundance in bacteria, catalytic and regulatory mechanisms of this class of enzymes are poorly understood. In particular, it is not clear if oligomerization is required for catalysis...

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PMID: 17640875
DOI: 10.1074/jbc.M704702200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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