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Article

Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast.

Molecular and cellular biology - 1 Dec 1998

Patel R C, Sen G C

Abstract excerpt

The roles of protein dimerization and double-stranded RNA (dsRNA) binding in the biochemical and cellular activities of PKR, the dsRNA-dependent protein kinase, were investigated. We have previously shown that both properties of the protein are mediated by the same domain. Here we show that dimerization is mediated by hydrophobic residues present on one side of an amphipathic alpha-helical structure within this...

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Identifiers

PMID: 9819388
DOI: 10.1128/MCB.18.12.7009
PMCID: PMC109283

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