Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma model

13 Jul 2009

Abstract excerpt

INTRODUCTION: Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS: Male NMRI mice were subjected to femur fracture/hemorrhagic shock and subsequent sepsis. Sham-operated animals were used as controls. DHEA (25 mg/kg) or vehicle was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Hormonal and reproductive studies
Share to Steroid Chemistry and Biochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19594900
DOI: 10.1186/cc7963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma modelPMID 19594900Read ↗

CD147 – an inducer of NF-κB within the post-traumatic immune response in a murine trauma modelSemantic proximity Read ↗

Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.Semantic proximity Read ↗

17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha.Semantic proximity Read ↗

Mapping the steroid response to major trauma from injury to recovery: a prospective cohort studySemantic proximity Read ↗

Acute Haemarthrosis in the Haemophilia A Rat Generates a Local and Systemic Proinflammatory Response.Semantic proximity Read ↗

Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response.Semantic proximity Read ↗

Significance of Serum mtDNA Concentration in Lung Injury Induced by Hip FractureSemantic proximity Read ↗

Femur fracture induces site-specific changes in T-cell immunity.Semantic proximity Read ↗

Gene Expression Profile of Steroid-induced Necrosis of Femoral Head of RatsSemantic proximity Read ↗

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.Semantic proximity Read ↗

Deleted form of hepatocyte growth factor ameliorates the mortality rate of severe thermal injury in rats.Semantic proximity Read ↗

Physiological role of tumor necrosis factor alpha in traumatic muscle injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.