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Article

Acute Haemarthrosis in the Haemophilia A Rat Generates a Local and Systemic Proinflammatory Response.

Thrombosis and haemostasis - 1 Nov 2017

Lövgren Karin M, Christensen Kristine R, Majewski Wiktor, Østrup Olga, Skov Søren, Wiinberg Bo

Abstract excerpt

Background Replacement therapy with coagulation factor VIII (FVIII) concurrent with bleeds (on-demand) in haemophilia A (HA) patients has been hypothesized to increase the risk for antidrug antibodies (inhibitors). A danger signal environment, characterized by tissue damage and inflammation at the site of a bleed, is thought to contribute to the anti-FVIII response. The nature of this inflammatory reaction is,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29202211
DOI: 10.1160/TH17-03-0149

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MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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