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Article

Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.

Journal of cellular physiology - 1 May 2007

Hsieh Ya-Ching, Frink Michael, Kawasaki Takashi, Thobe Bjoern M, Choudhry Mashkoor A, Schwacha Martin G, Bland Kirby I, Chaudry Irshad H

Abstract excerpt

Toll-like receptor 4 (TLR4) mediates mitochondrial DNA (mtDNA) damage and biogenic responses. Mitochondrial transcription factor A (Tfam) is an essential regulator for mtDNA transcription and ATP production. Increased ATP levels were associated with normalization of immune function following trauma-hemorrhage. Moreover, administration of 17beta-estradiol following trauma-hemorrhage upregulates cardiac Tfam and...

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Identifiers

PMID: 17219405
DOI: 10.1002/jcp.20943

Genes

TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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