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Article

Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes.

European journal of haematology - 1 Nov 2009

Peter Anita, Heiden Thomas, Taube Tillmann, Körner Gabriele, Seeger Karl

Abstract excerpt

OBJECTIVES: TEL/AML1 (ETV6/RUNX1) fusion resulting from the translocation t(12;21)(p13;q22) constitutes the most common chimeric fusion gene in initial childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) (19-27%) and has been associated with good prognosis. Three secondary aberrations in TEL/AML1 positive ALL have been suspected to negatively influence outcome: deletion of the second TEL allele...

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Share to Chromosomes, Human, Pair 12
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 19594616
DOI: 10.1111/j.1600-0609.2009.01315.x

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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