Immunogenotype changes prevail in relapses of young children with TEL-AML1-positive acute lymphoblastic leukemia and derive mainly from clonal selection.

doi:10.1158/1078-0432.CCR-05-1239

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Article

Immunogenotype changes prevail in relapses of young children with TEL-AML1-positive acute lymphoblastic leukemia and derive mainly from clonal selection.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2005

Panzer-Grümayer E Renate, Cazzaniga Giovanni, van der Velden Vincent H J, del Giudice Laura, Peham Martina, Mann Georg, Eckert Conny, Schrauder Andre, Germano Giuseppe, Harbott Jochen, Basso Giuseppe, Biondi Andrea, van Dongen Jacques J M, Gadner Helmut, Haas Oskar A

Abstract excerpt

PURPOSE: Variations of the immunogenotype and TEL deletions in children with TEL-AML1+ acute lymphoblastic leukemia support the hypothesis that relapses derive from a persistent TEL-AML1+ preleukemic/leukemic clone rather than a resistant leukemia. We aimed at elucidating the relationship between the immunogenotype patterns at diagnosis and relapse as well as their clinical and biological relevance. PATIENTS AND...

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PMID: 16278392
DOI: 10.1158/1078-0432.CCR-05-1239

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