Article
MTHFR C677T genotype frequency in patients of Middle Eastern descent as determined by real-time PCR and melting curve analysis.
Genetic testing and molecular biomarkers - 1 Aug 2009
Haghighatgoo Arman, Valles-Ayoub Yadira, Saechao Chai, Esfandiarifard Saghi, Martinez Sarah L, Pietruszka Marvin, Darvish Daniel
Abstract excerpt
The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism produces an elevation in plasma homocysteine concentrations when present in the homozygous state. Increased homocysteine levels have been associated with a greater risk for vascular diseases, including cardiovascular di...
Topics
- Asian People
- Cardiovascular Diseases
- DNA
- DNA Probes
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Heterozygote
- Homozygote
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle East
- Mutation
- Polymerase Chain Reaction