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Article

Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2008

Kristensen Lasse S, Dobrovic Alexander

Abstract excerpt

High-resolution melting (HRM) shows great promise for high-throughput, rapid genotyping of individual polymorphic loci. We have developed HRM assays for genotyping single nucleotide polymorphisms (SNP) in several key genes that are involved in methyl metabolism and may directly or indirectly affect the methylation status of the DNA. The SNPs are in the 5,10-methylenetetrahydrofolate reductase (MTHFR; C677T and...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methyltransferase 3B

Share to DNA, Neoplasm

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 18483346
DOI: 10.1158/1055-9965.EPI-07-2531

Genes

MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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