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Article

Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia.

Saudi medical journal - 1 Dec 2005

Al-Ali Amein K, Al-Muhana Fahad A, Larbi Emmanuel B, Abdulmohsen Mohammed F, Al-Sultan Ali I, Al-Maden Mohamed S, Al-Ateeq Suad A

Abstract excerpt

OBJECTIVE: Homozygosity for the C677T mutation in the gene of the thermolabile enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) associates with reduced enzyme activity, leading to mild hyperhomocysteinemia. We now know that an elevated level of homocysteine is an important risk factor for cardiovascular disease (CVD). The objective of this study was to determine the prevalence of the C677T mutation in...

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Identifiers

PMID: 16380767

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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