Article
Role of CYP450 in pharmacokinetics and pharmacogenetics of antihypertensive drugs.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria - 1 Jan 2000
Rodríguez Arcas M J, García-Jiménez E, Martínez-Martínez F, Conesa-Zamora P
Abstract excerpt
INTRODUCTION: Antihypertensive drugs are principally metabolised by enzymes of the P450 (CYP450) cytochrome family. Response to hypertensive treatment whose genetic basis is beginning to be known presents inter-individual differences among patients. OBJECTIVE: The aim of this review is to document the role of cytochrome enzymes P450 in the metabolising process of antihypertensive drugs, and to identify the most...
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