Article
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nature genetics - 1 May 2010
Freathy Rachel M, Mook-Kanamori Dennis O, Sovio Ulla, Prokopenko Inga, Timpson Nicholas J, Berry Diane J, Warrington Nicole M, Widen Elisabeth, Hottenga Jouke Jan, Kaakinen Marika, Lange Leslie A, Bradfield Jonathan P, Kerkhof Marjan, Marsh Julie A, Mägi Reedik, Chen Chih-Mei, Lyon Helen N, Kirin Mirna, Adair Linda S, Aulchenko Yurii S, Bennett Amanda J, Borja Judith B, Bouatia-Naji Nabila, Charoen Pimphen, Coin Lachlan J M, Cousminer Diana L, de Geus Eco J C, Deloukas Panos, Elliott Paul, Evans David M, Froguel Philippe, Glaser Beate, Groves Christopher J, Hartikainen Anna-Liisa, Hassanali Neelam, Hirschhorn Joel N, Hofman Albert, Holly Jeff M P, Hyppönen Elina, Kanoni Stavroula, Knight Bridget A, Laitinen Jaana, Lindgren Cecilia M, McArdle Wendy L, O'Reilly Paul F, Pennell Craig E, Postma Dirkje S, Pouta Anneli, Ramasamy Adaikalavan, Rayner Nigel W, Ring Susan M, Rivadeneira Fernando, Shields Beverley M, Strachan David P, Surakka Ida, Taanila Anja, Tiesler Carla, Uitterlinden Andre G, van Duijn Cornelia M, Wijga Alet H, Willemsen Gonneke, Zhang Haitao, Zhao Jianhua, Wilson James F, Steegers Eric A P, Hattersley Andrew T, Eriksson Johan G, Peltonen Leena, Mohlke Karen L, Grant Struan F A, Hakonarson Hakon, Koppelman Gerard H, Dedoussis George V, Heinrich Joachim, Gillman Matthew W, Palmer Lyle J, Frayling Timothy M, Boomsma Dorret I, Davey Smith George, Power Chris, Jaddoe Vincent W V, Jarvelin Marjo-Riitta, McCarthy Mark I
Abstract excerpt
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently...
