Article
The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients.
Autonomic neuroscience : basic & clinical - 1 Sept 2017
Tyrrell Christina, Toyooka Amanda, Khan Faiza, Thornburg Kent L, Mudd James O, Hasan Wohaib
Abstract excerpt
Thromboembolic complications are a significant cause of mortality and re-hospitalization in heart failure (HF) patients. One source of thrombi is the ventricular endocardial surface that becomes increasingly pro-thrombotic as HF progresses. Anticoagulation comes with bleeding risks so identifying therapeutic agents for improving cardiac endothelial health are of critical clinical importance. Endocardial...
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