Article
The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.
Journal of bacteriology - 1 Sept 2009
Fontán P A, Voskuil M I, Gomez M, Tan D, Pardini M, Manganelli R, Fattorini L, Schoolnik G K, Smith I
Abstract excerpt
The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under...
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