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Article

The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.

Infection and immunity - 1 May 2004

Manganelli Riccardo, Fattorini Lanfranco, Tan Dejiang, Iona Elisabetta, Orefici Graziella, Altavilla Giuseppe, Cusatelli Paola, Smith Issar

Abstract excerpt

The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15102817
DOI: 10.1128/IAI.72.5.3038-3041.2004
PMCID: PMC387853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.PMID 15102817Read ↗

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