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Article

Genetic analysis of age at onset variation in spinocerebellar ataxia type 2

16 May 2017

Abstract excerpt

Objective: To examine heritability of the residual variability of spinocerebellar ataxia type 2 (SCA2) age at onset (AO) after controlling for CAG repeat length. Methods: From 1955 to 2001, dates of birth, CAG repeat lengths, AO, sex, familial inheritances, and clinical manifestations were collected for a large Cuban SCA2 cohort of 382 affected individuals, including 129 parent-child pairs and 69 sibships....

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PMID: 28534046
DOI: 10.1212/nxg.0000000000000155

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