Article
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Takeda Kohsuke, Komuro Yoshiko, Hayakawa Teruyuki, Oguchi Haruka, Ishida Yosuke, Murakami Shiori, Noguchi Takuya, Kinoshita Hideyuki, Sekine Yusuke, Iemura Shun-ichiro, Natsume Tohru, Ichijo Hidenori
Abstract excerpt
Phosphoglycerate mutase (PGAM) is an enzyme of intermediary metabolism that converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis. Here, we discovered PGAM5 that is anchored in the mitochondrial membrane lacks PGAM activity and instead associates with the MAP kinase kinase kinase ASK1 and acts as a specific protein Ser/Thr phosphatase that activates ASK1 by dephosphorylation of inhibitory sites....
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