Article
N-acetylation and hydroxylation polymorphisms in type II diabetics with microvascular disturbances.
European journal of clinical pharmacology - 1 Jan 1997
Gawrońska-Szklarz B, Górnik W, Pawlik A, Kunicki P, Wójcicki J, Sitkiewicz D, Sych Z
Abstract excerpt
The N-acetylation and hydroxylation (CYP2D6) genetic polymorphisms were assessed in 43 healthy subjects and in 84 type II (non-insulin-dependent) diabetics. The proportions of slow and fast acetylators as well as poor and extensive metabolisers in a group of diabetics suffering from microvascular disturbances (nephropathy, retinopathy and neuropathy) were compared with the control group and with diabetics without...
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