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Regulation of Replicative and Stress-Induced Senescence by RSK4, which is Down-regulated in Human Tumors

7 Jul 2009

Abstract excerpt

PURPOSE: The control of senescence and its biochemical pathways is a crucial factor for understanding cell transformation. In a large RNA interference screen, the RSK4 gene was found to be related to p53-dependent arrest. The purpose of the present study was to investigate the potential role of RSK4 as a tumor suppressor gene. EXPERIMENTAL DESIGN: RSK4 expression was determined by quantitative real-time PCR and...

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PMID: 19584160
DOI: 10.1158/1078-0432.ccr-08-3159

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