Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting α subunit of protein kinase CKII in human colorectal cancer cells

5 Nov 2012

Abstract excerpt

We previously demonstrated that downregulation of protein kinase CKII induces cellular senescence in human colon cancer HCT116 cells. To investigate the role of microRNAs (miRNAs) in CKII downregulation during senescence, we employed computational algorithms. Four miRNAs (miR-186, miR-216b, miR-337-3p, and miR-760) were predicted to be miRNAs against CKIIα mRNA. Mimics of all four miRNAs jointly downregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular RNAs in diseases
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23137536
DOI: 10.1016/j.bbrc.2012.10.117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting α subunit of protein kinase CKII in human colorectal cancer cellsPMID 23137536Read ↗

Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells.Semantic proximity Read ↗

Regulation of Replicative and Stress-Induced Senescence by RSK4, which is Down-regulated in Human TumorsSemantic proximity Read ↗

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.Semantic proximity Read ↗

Comprehensive genomics analysis of aging related gene signature to predict the prognosis and drug resistance of colon adenocarcinomaSemantic proximity Read ↗

A novel cell senescence-related IncRNA survival model associated with the tumor immune environment in colorectal cancerSemantic proximity Read ↗

Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivitySemantic proximity Read ↗

Integrative Machine Learning and Bioinformatics Analysis to Identify Cellular Senescence-Related Genes and Potential Therapeutic Targets in Ulcerative Colitis and Colorectal CancerSemantic proximity Read ↗

A novel senescence-associated LncRNA signature predicts the prognosis and tumor microenvironment of patients with colorectal cancer: a bioinformatics analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.