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PIK3R3 inhibits cell senescence through p53/p21 signaling

24 Sept 2020

Abstract excerpt

Cellular senescence is a stress response of human cells that removes potentially harmful cells by initiating cell cycle arrest. Inducing senescence of tumor cells may be an effective tumor-inhibiting strategy. In this study we found that PIK3R3 could inhibit the cell senescence of colorectal cancer cells and promote cell proliferation through the p53/p21 signal pathway. PIK3R3 could bind to p53 and inhibit the...

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PMID: 32973127
DOI: 10.1038/s41419-020-02921-z

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