Article
Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus.
Human molecular genetics - 1 Oct 2009
Sánchez Elena, Palomino-Morales Rogelio J, Ortego-Centeno Norberto, Jiménez-Alonso Juan, González-Gay Miguel A, López-Nevot Miguel A, Sánchez-Román Julio, de Ramón Enrique, González-Escribano M Francisca, Pons-Estel Bernardo A, D'Alfonso Sandra, Sebastiani Gian Domenico, Alarcón-Riquelme Marta E, Martín Javier
Abstract excerpt
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in chronic inflammation and autoimmune disorders. In this study, we aimed to determine the potential role of the IL18 gene in SLE. To define the genetic association of the IL18 and SLE, we have genotyped nine SNPs in an independent set of Spanish cases and controls. The IL18 polymorphisms were genotyped by PCR, using a predeveloped...
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