Article
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
Oncogene - 28 Mar 2013
Castillo-Lluva S, Tan C-T, Daugaard M, Sorensen P H B, Malliri A
Abstract excerpt
The small GTPase Rac1 is a key regulator of cell motility. Multiple mechanisms regulate Rac1 activity including its ubiquitylation and subsequent degradation. Here, we identify the tumour suppressor HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) as an E3 ubiquitin ligase responsible for Rac1 degradation following activation by a migration stimulus. We show that HACE1 and Rac1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.