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Article

Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.

Cytokine - 1 Aug 2012

Wang Yue, Li Lingzhi, Guo Xiaoqin, Jin Xin, Sun Weijia, Zhang Xiaolei, Xu Rui Cheng

Abstract excerpt

It has been widely reported that Interleukin-6 (IL-6) is overexpressed in the serum and ascites of ovarian cancer (OVCA) patients, and elevated IL-6 level correlates with poor prognosis and survival. However, the exact role that IL-6 plays in this malignancy or whether IL-6 can regulate tumorigenic properties has not been established. Here we demonstrate that overexpression of IL-6 in non-IL-6-expressing A2780...

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PMID: 22595649
DOI: 10.1016/j.cyto.2012.04.020

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