Article
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.
Oncogene - 3 Sept 2009
Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G
Abstract excerpt
The transcription factor p73, a member of the p53 family, mediates cell-cycle arrest and apoptosis in response to DNA damage-induced cellular stress, acting thus as a proapoptotic gene. Similar to p53, p73 activity is regulated by post-translational modification, including phosphorylation, acetylation and ubiquitylation. In C. elegans, the F-box protein FSN-1 controls germline apoptosis by regulating CEP-1, the...
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