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Article

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

Nature genetics - 1 Feb 2003

Bergamaschi Daniele, Samuels Yardena, O'Neil Nigel J, Trigiante Giuseppe, Crook Tim, Hsieh Jung-Kuang, O'Connor Daniel J, Zhong Shan, Campargue Isabelle, Tomlinson Matthew L, Kuwabara Patricia E, Lu Xin

Abstract excerpt

We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p53 (ref. 1). Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the...

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PMID: 12524540
DOI: 10.1038/ng1070

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