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Article

The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.

The Journal of biological chemistry - 30 Nov 2012

Lu Yunzhe, Li Jiezhi, Cheng Dongmei, Parameswaran Balaji, Zhang Shaohua, Jiang Zefei, Yew P Renee, Peng Junmin, Ye Qinong, Hu Yanfen

Abstract excerpt

BRCA1 mutations account for a significant proportion of familial breast and ovarian cancers. In addition, reduced BRCA1 protein is associated with sporadic cancer cases in these tissues. At the cellular level, BRCA1 plays a critical role in multiple cellular functions such as DNA repair and cell cycle checkpoint control. Its protein level is regulated in a cell cycle-dependent manner. However, regulation of BRCA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23086937
DOI: 10.1074/jbc.M112.407106
PMCID: PMC3510804

Genes

BRCA1
FBXO44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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