Article

Ligand Entry into Fatty Acid Binding Protein via Local Unfolding instead of Gap Widening

2019-09-25

Abstract excerpt

Fatty acid binding proteins (FABPs) play an important role in transportation of fatty acids. Despite intensive studies, how fatty acids enter the protein cavity for binding is still controversial. Here, a gap-closed variant of human intestinal FABP was generated by mutagenesis, in which the gap is locked by a disulfide bridge. According to its structure determined here by NMR, this variant has no obvious openings...

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Literature Corpus work: 52abf7c5-9802-590a-8905-3d2c00920729
DOI: 10.1101/782664

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