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Article

Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates.

PloS one - 1 Jan 2011

Baatz Franky, Nijhuis Monique, Lemaire Morgane, Riedijk Martiene, Wensing Annemarie M J, Servais Jean-Yves, van Ham Petra M, Hoepelman Andy I M, Koopmans Peter P, Sprenger Herman G, Devaux Carole, Schmit Jean-Claude, Perez Bercoff Danielle

Abstract excerpt

Resistance mutations to the HIV-1 fusion inhibitor enfuvirtide emerge mainly within the drug's target region, HR1, and compensatory mutations have been described within HR2. The surrounding envelope (env) genetic context might also contribute to resistance, although to what extent and through which determinants remains elusive. To quantify the direct role of the env context in resistance to enfuvirtide and in...

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Share to Enfuvirtide
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp41

Share to HIV Fusion Inhibitors

Share to Inhibitory Concentration 50

Share to Peptide Fragments

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Source

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Identifiers

PMID: 21760896
DOI: 10.1371/journal.pone.0021535
PMCID: PMC3132734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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