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Article

Genotyping and Quantifying Lyme Pathogen Strains by Deep Sequencing of the Outer Surface Protein C (ospC) Locus.

Journal of clinical microbiology - 1 Nov 2018

Di Lia, Wan Zhenmao, Akther Saymon, Ying Chunxiao, Larracuente Amanda, Li Li, Di Chong, Nunez Roy, Cucura D Moses, Goddard Noel L, Krampis Konstantino, Qiu Wei-Gang

Abstract excerpt

A mixed infection of a single tick or host by Lyme disease spirochetes is common and a unique challenge for the diagnosis, treatment, and surveillance of Lyme disease. Here, we describe a novel protocol for differentiating Lyme strains on the basis of deep sequencing of the hypervariable outer surface protein C locus (ospC). Improving upon the traditional DNA-DNA hybridization method, the next-generation...

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Identifiers

PMID: 30158192
DOI: 10.1128/JCM.00940-18
PMCID: PMC6204676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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