Article

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C ( <i>ospC</i> ) amplicons

2018-06-04

Abstract excerpt

Mixed infection of a single tick or host by Lyme disease spirochetes is common and a unique challenge for diagnosis, treatment, and surveillance of Lyme disease. Here we describe a novel protocol for differentiating Lyme strains based on deep sequencing of the hypervariable outer-surface protein C locus ( ospC ). Improving upon the traditional DNA-DNA hybridization method, the next-generation sequencing-based pro...

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Literature Corpus work: 887332b9-c55d-588d-9b5b-e6c18e29e136
DOI: 10.1101/332072

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