Article
The genetic basis of colorectal cancer--clinical implications.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Feb 1995
Tsiotou A G, Krespis E N, Sakorafas G H, Krespi A E
Abstract excerpt
Colorectal carcinomas demonstrate extensive molecular genetic alterations throughout the genome. The genetic changes in cancer of the colon and rectum are among the best understood of any common human cancer. The genetic abnormalities include both dominant-acting oncogenes (Ki-ras, c-src) and tumor-suppressor genes which undergo inactivation or loss (APC, DCC, p53). The evolution of the cancer is a complicated...
Topics
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Mutation
- Oncogenes