Article
Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion.
American journal of hypertension - 1 Sept 2009
Dumont Julie, Meroufel Djabaria, Bauters Christophe, Hansmannel Franck, Bensemain Faïza, Cottel Dominique, Hamon Martial, Lambert Jean-Charles, Ducimetière Pierre, Amouyel Philippe, Zureik Mahmoud, Brousseau Thierry
Abstract excerpt
BACKGROUND: Previous studies have suggested that the activity of enzymes involved in the urea cycle may modulate nitric oxide (NO) production, arterial vasomotion, and hypertension. Our aim was to determine whether hypertension and coronary vasomotion could be associated with polymorphisms within the ornithine transcarbamylase (OTC) gene, located on chromosome X and coding for a key-enzyme of the urea cycle....
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