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Article

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

Neuroscience letters - 2 Jan 2009

Hansmannel Franck, Lendon Corinne, Pasquier Florence, Dumont Julie, Hannequin Didier, Chapuis Julien, Laumet Geoffroy, Ayral Anne-Marie, Galimberti Daniela, Scarpini Elio, Campion Dominique, Amouyel Philippe, Lambert Jean-Charles

Abstract excerpt

Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffering from Alzheimer's Disease (AD). Association studies in a population from northern France have revealed that two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD. In the present work, these association studies were extended...

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Source

Identifiers

PMID: 18983895
DOI: 10.1016/j.neulet.2008.10.081

Genes

OTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?PMID 18983895Read ↗

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