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Article

Metal ion CHElate-aSSisted LIGAtion (CHESS LIGA) for SNP detection on microarrays.

Bioorganic & medicinal chemistry letters - 1 Aug 2009

Le Thi Hien, Oretskaya Tatiana S, Zatsepin Timofei S

Abstract excerpt

We developed a metal ion chelate-assisted ligation for SNP detection by microarray. An oligonucleotide probe was separated into two 9-10-mers bearing iminodiacetic residues at the gap point. Duplex formation with the DNA target was possible only if nickel ions were added, but a nucleotide substit...

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PMID: 19574044
DOI: 10.1016/j.bmcl.2009.06.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19574044-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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