Article
An approach toward SNP detection by modulating the fluorescence of DNA-templated silver nanoclusters.
Biosensors & bioelectronics - 15 May 2013
Park Juhee, Lee Jihyun, Ban Changill, Kim Won Jong
Abstract excerpt
A rapid, homogeneous, and in-situ labelable format designed to detect single nucleotide polymorphism (SNP) is presented. Fluorescent silver nanoclusters produced following hydride-mediated reduction of Ag(+) bound to a partial double-stranded oligodeoxynucleotide were employed as probes for SNPs. The sensing mechanism is based on the fluorescence enhancement of silver nanoclusters through an irreversible cluster...
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