Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy

12 Dec 2003

Abstract excerpt

The hyperglycemia of maternal diabetes suppresses the glucose transporter-1 (GLUT1) facilitative glucose transporter 49-66% in preimplantation embryos. Glucose uptake is reduced and apoptosis is activated. We hypothesized that the reduction of embryonic GLUT1 may play a key role in the malformations of diabetic embryopathy. Therefore, we produced GLUT1-deficient transgenic mice [i.e., antisense-GLUT1 (GT1AS)] to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Gestational Diabetes Research and Management
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14673082
DOI: 10.1073/pnas.2536196100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathyPMID 14673082Read ↗

Glucose metabolism in pregnancy and embryogenesisSemantic proximity Read ↗

Diabetes and Preimplantation Events of EmbryogenesisSemantic proximity Read ↗

One-Cell Zygote Transfer from Diabetic to Nondiabetic Mouse Results in Congenital Malformations and Growth Retardation in OffspringSemantic proximity Read ↗

Effect of maternal diabetes on the embryo, fetus, and children: Congenital anomalies, genetic and epigenetic changes and developmental outcomesSemantic proximity Read ↗

Impact of hyperglycemia on early embryo development and embryopathy: in vitro experiments using a mouse modelSemantic proximity Read ↗

Diabetic Embryopathy: A Developmental Perspective from Fertilization to AdulthoodSemantic proximity Read ↗

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes.Semantic proximity Read ↗

Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53.Semantic proximity Read ↗

GLUT1 deficiency links nutrient availability and apoptosis during embryonic development.Semantic proximity Read ↗

Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo.Semantic proximity Read ↗

The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.Semantic proximity Read ↗

Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.