Effect of bis(beta-chloroethyl)sulfide (BCES) on base mismatch repair of DNA in monkey kidney cells.

doi:10.1016/0041-008x(91)90027-c

Back to search

Article

Effect of bis(beta-chloroethyl)sulfide (BCES) on base mismatch repair of DNA in monkey kidney cells.

Toxicology and applied pharmacology - 1 Nov 1991

Fan L J, Bernstein I A

Abstract excerpt

Sulfur mustard, bis(beta-chloroethyl)sulfide (BCES), a bifunctional alkylating agent, is a vesicant whose mode of action involves interference with the integrity of cellular DNA. Alkylation of DNA is responsible for some of the biological effects of BCES in tissue. Another possible mechanism by w...

Topics

Animals
Base Composition
Cells, Cultured
Chlorocebus aethiops
DNA Repair
DNA Replication
DNA, Viral
Electrophoresis, Agar Gel
Kidney
Mustard Gas
Mutation
Temperature

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.