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Article

Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.

PloS one - 1 Jul 2009

Gombert Wendy M, Krumm Anton

Abstract excerpt

BACKGROUND: Insulators and domain boundaries both shield genes from adjacent enhancers and inhibit intrusion of heterochromatin into transgenes. Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were randomly inserted into the genome by transfection. However, the contribution of CTCF binding sites to both gene...

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Share to Acetylation
Share to CCCTC-Binding Factor
Share to Genes, myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Recombination, Genetic

Share to Repressor Proteins

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Share to Sequence Deletion

Share to Transcription, Genetic

Source

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Identifiers

PMID: 19568426
DOI: 10.1371/journal.pone.0006109
PMCID: PMC2699473

Genes

CTCF
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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