Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements.

The Journal of biological chemistry - 8 Jun 2001

Albert T, Wells J, Funk J O, Pullner A, Raschke E E, Stelzer G, Meisterernst M, Farnham P J, Eick D

Abstract excerpt

The proto-oncogene c-myc is transcribed from a dual promoter P1/P2, with transcription initiation sites 160 base pairs apart. Here we have studied the transcriptional activation of both promoters on chromatin templates. c-myc chromatin was reconstituted on stably transfected, episomal, Epstein-Barr virus-derived vectors in a B cell line. Episomal P1 and P2 promoters showed only basal activity but were strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Genes, myc

Share to Plasmids

Share to Promoter Regions, Genetic

Share to Protein Conformation

Share to Proto-Oncogene Mas

Source

Identifiers

PMID: 11279041
DOI: 10.1074/jbc.M100265200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements.PMID 11279041Read ↗

Differential regulation of the c-MYC P1 and P2 promoters in the absence of functional tumor suppressors: implications for mechanisms of deregulated MYC transcription.Semantic proximity Read ↗

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.Semantic proximity Read ↗

c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.Semantic proximity Read ↗

Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.Semantic proximity Read ↗

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Semantic proximity Read ↗

Differential modulation of cyclin gene expression by MYC.Semantic proximity Read ↗

Positive and negative regulation of granulocyte-macrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2Semantic proximity Read ↗

Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.Semantic proximity Read ↗

Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.Semantic proximity Read ↗

Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.Semantic proximity Read ↗

Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.Semantic proximity Read ↗

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.