Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation With Hepatocellular Proliferation

30 Jun 2009

Abstract excerpt

Recombinant adeno-associated virus vectors (rAAVs) show exceptional promise for liver-targeted gene therapy, with phenotype correction in small and large animal disease models being reported with increasing frequency. Success in humans, however, remains a considerable challenge that demands greater understanding of host-vector interactions, notably those governing the efficiency of initial gene transfer and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral Infections and Immunology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19568224
DOI: 10.1038/mt.2009.139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation With Hepatocellular ProliferationPMID 19568224Read ↗

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.Semantic proximity Read ↗

Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transferSemantic proximity Read ↗

Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate MuscleSemantic proximity Read ↗

Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in MiceSemantic proximity Read ↗

Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effectsSemantic proximity Read ↗

Constitutively active STAT5b feminizes mouse liver gene expressionSemantic proximity Read ↗

Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal TestisSemantic proximity Read ↗

Constitutively Active STAT5b Feminizes Mouse Liver Gene ExpressionSemantic proximity Read ↗

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in miceSemantic proximity Read ↗

Incomplete elimination of viral genomes is associated with chronic inflammation in nonhuman primate livers after AAV-mediated gene transferSemantic proximity Read ↗

Recombinant covalently closed circular DNA of hepatitis B virus induces long‐term viral persistence with chronic hepatitis in a mouse modelSemantic proximity Read ↗

Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy ProtocolsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.