Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2008

Cunningham Sharon C, Dane Allison P, Spinoulas Afroditi, Logan Grant J, Alexander Ian E

Abstract excerpt

Recombinant adeno-associated viral (rAAV) vectors have shown promise for use in liver-targeted gene delivery, but their effects have not been extensively investigated in the immature liver. Understanding the impact of liver growth on the efficacy of transduction is essential, because many monogenic liver diseases that are amenable to gene therapy will require treatment early in life. Here we show that rAAV2/8...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Genetic Therapy

Share to Genetic Vectors

Share to Genome

Share to Immune System

Share to Transgenes

Source

Identifiers

PMID: 18414478
DOI: 10.1038/mt.2008.72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.PMID 18414478Read ↗

Hepatic Gene Transfer in Neonatal Mice by Adeno-Associated Virus Serotype 8 VectorSemantic proximity Read ↗

AAV8-mediated Hepatic Gene Transfer in Infant Rhesus Monkeys (Macaca mulatta)Semantic proximity Read ↗

Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation With Hepatocellular ProliferationSemantic proximity Read ↗

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 VectorsSemantic proximity Read ↗

Adeno‐associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo†‡Semantic proximity Read ↗

AAV8 Gene Therapy Rescues the Newborn Phenotype of a Mouse Model of Crigler-Najjar.Semantic proximity Read ↗

Safe and effective liver-directed AAV-mediated homology-independent targeted integration in mouse models of inherited diseasesSemantic proximity Read ↗

Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effectsSemantic proximity Read ↗

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in miceSemantic proximity Read ↗

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectorsSemantic proximity Read ↗

Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytesSemantic proximity Read ↗

Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.