Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Abstract excerpt

Progression in pediatric brain tumor growth is thought to be the net result of signaling through various protein kinase-mediated networks driving cell proliferation. Defining new targets for treatment of human malignancies, without a priori knowledge on aberrant cell signaling activity, remains exceedingly complicated. Here, we introduce kinome profiling using flow-through peptide microarrays as a new concept for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Chromatin Dynamics
• Share to Glioma Diagnosis and Treatment
• Share to Protein Degradation and Inhibitors