Article
Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines.
Molecular & cellular proteomics : MCP - 1 May 2020
van Alphen Carolien, Cloos Jacqueline, Beekhof Robin, Cucchi David G J, Piersma Sander R, Knol Jaco C, Henneman Alex A, Pham Thang V, van Meerloo Johan, Ossenkoppele Gert J, Verheul Henk M W, Janssen Jeroen J W M, Jimenez Connie R
Abstract excerpt
Acute myeloid leukemia (AML) is a clonal disorder arising from hematopoietic myeloid progenitors. Aberrantly activated tyrosine kinases (TK) are involved in leukemogenesis and are associated with poor treatment outcome. Kinase inhibitor (KI) treatment has shown promise in improving patient outcome in AML. However, inhibitor selection for patients is suboptimal.In a preclinical effort to address KI selection, we...
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